Internal Medicine Today
Volume:20 Issue: 4, 2015

Gastric cancer is the most common cancer in men and the third most common cancer in women after breast cancer and colon. This study aimed to compare the complications and survival of two manual and suturing and suturing with stapler in esophagojejunostomy suturing followed by total gastrectomy. In this historical cohort study, 116 patients requiring total Gastrectomy were studied with proximal Gastric and Cardia cancer referred to a hospital with census method. Patients were studied by age, gender, type of surgery, leakage and other complications and one-year survival rates during hospitalization and at least 12 months after surgery. Data analyzed by SPSS 20 software and Chi-square, Independent-T tests, Kaplan-Meier and Cox regression. Suturing in 40 patients (34.5%) was manually and in 76 patients (65.5%) was with stapler. In manual suturing, 6 (15%) and in stapler suturing 2 (2.6%) leakage happened, which was statistically different (p=0.18). Mean operation time was 273.9±50.7min in manual suturing and was 252.3±65.8 in stapler suturing which was statistically different (p=0.25). In manual suturing 8 (20%) and in stapler suturing 4 (5.3%) deaths occurred which was statistically different (p=0.009). One-year survival rate was 31% and median survival rate was 15 months. Age and stage of disease had the highest correlation with survival rate. Due to the lower leakage rate and mortality after surgery, manual suturing is more effective than suturing with stapler.

Ziziphora tenuior L. is used as an analgesic and to treat digestive diseases in Iranian traditional medicine. This study aimed to evaluate the analgesic effect of hydroalcoholic extract of Ziziphora tenuior L. on pain and compare it with Diclofenac in male rats. This Experimental study was done on 72 male rats. Animals were randomly divided into 9 group (n=8) including C (with no treatment), P (Placebo receiving water and alcohol), K400, K800, and K1600 (receiving the extract 400, 800, and 1600mg/kg doses respectively), DK1600 (receiving 0.4mg/kg Diclophenac and 1600mg/kg dose of the extract), N (receiving Naloxan), and M (receiving Morphine). 15min after each oral administration, animals were injected with formalin and animal movements and behavior were recorded in two acute and chronic phases. Data were analyzed by SPSS 22 software using Tukey and One-way ANOVA tests. Pain score in PC group reduced significantly compared to C group (p≤0.05). Pain significantly decreased in K400, K800 and K1600 groups compared with control group (p≤0.05). Pretreatment with Naloxone significantly reduced analgesic effect of the extract compared with control group (p≤0.05). Ziziphora tenuior L. decreases pain that might be caused by compounds such as Limonene and Pulegone especially.

Urine retention following surgery can lead to performance and basic disorders in gall bladder. The purpose of this study was to explore the effect of feet reflexology on urinary retention relieving after surgery. This clinical trial was done in 2014 on 70 patients with urinary retention following surgery that was not able to urinate despite routine nursing measures. The patients were divided into two interventional and control groups based on random allocation (permutation blocking method). Reflexology was performed for intervention group for 30min (15min for each foot); and general reflexology was carried out for control group for the same duration. Data collected using a researcher-made checklist. Data were analyzed by SPSS 16 using descriptive statistics, independent-T, Man-Whitney, and Chi-square tests. There was a significant difference between intervention and control groups regarding urinary retention after surgery (p=0.04) and retention time (p<0.001). However, a significant difference was not found between two groups in volume of excreted urine (p=0.2). Feet reflexology has positive effect on urinary retention after surgery.

Trichomoniasis is the most common sexually-transmitted disease in the world. This study aimed to investigate the prevalence of Trichomonas vaginalis by PCR referred to the women clinics of Tehran City. This cross-sectional study was done on 140 women admitted to Tehran Loghman and Shahid Shoorideh clinics hospital from November 2013 to December 2014. Demographic data were collected by a questionnaire. Using 2 swabs, from the posterior fornix of the vagina, secretions were collected with a swab to examine in the vaginal TYI-S-33 culture and another for molecular detection placed in a tube containing 2ml of sterile saline and transferred to the laboratory. Data were analyzed by SPSS 11 and One-sample T test. Of 46 suspected patients with Trichomonas vaginalis infection, vaginal secretions of 11 (7.8%) patients and urine samples of 4 (2.8%) patients by PCR, vaginal secretions of 6 (4.2%) and urine sample of 1 (0.5%) were reported positive in culture. There was a significant correlation between education and husbands’ job and Trichomonas vaginalis infection (p<0.05). There was not a significant correlation between contraception and prevalence of Trichomonas vaginalis (p>0.05). Employing new molecular methods based on PCR is recommended as a supplement or alternative to current methods for detection of Trichomonas vaginalis.

Alpha tumor necrosis factor and Hydrogen peroxide increase in neurotrophins expression in several brain structures. The purpose of this study was to investigate the interactive effect of Hydrogen peroxide and neurotrophic tumor necrosis factor with brain-derived neurotrophic factor by glial cell-derived neurotrophic factor after severe exercise. This experimental study was done on 16 adult Wistar albino rats 280g and 3months old. Animals were divided into two intense exercise and sedentary control groups. Animals ran for 6 weeks, 6 days a week, at the speed of 27m per minute and on treadmill for 60 minutes daily. Using kit, the content of BDNF, GDNF, and TNF-α were measured using sandwich ELISA and hydrogen peroxide levels was analyzed by colorimetric assay. Data analyzed by SPSS 16 and Independent-T test. Hydrogen peroxide levels in the brain, in intense exercise group increased significantly compared with control group (p= 0.006). TNF-α, GDNF and BDNF Levels in the brain in intense exercise group significantly increased compared with control group (p=0.001). Intense running on treadmill increase BDNF and GDNF content in brain of albino Wistar rats through increasing the H2O2 and TNF-α levels.

Endotracheal intubation can increase sympathetic reflex activity result in blood pressure increase, arrhythmia and tachycardia. This study aimed to compare the effects of Clonidine premedication and Fentanyl on hemodynamic factors (heart rate, systolic and diastolic blood pressure) in opium-dependent patients under endotracheal intubation. This single-blind clinical trial was done on 60 opium-dependent patients undergoing elective surgery under general anesthesia with endotracheal intubation in 2013 at operating room of 15 Khordad hospital. The samples were divided randomly into two equal groups receiving Clonidine and Fentanyl. Systolic and diastolic blood pressure and heart rate were compared before, immediately and 5min after intubation. Data were analyzed using Independent-T, ANOVA and Pearson correlation coefficient tests by SPSS 16 Software. The mean heart rate, systolic and diastolic blood pressure before endotracheal intubation in both groups was not statistically different (p>0.05) but the mean heart rate, systolic and diastolic blood pressure, immediately after intubation in both groups was maximum and showed significant difference statistically (p<0.001). Systolic and diastolic blood pressure in Clonidine group, 5min after intubation significantly decreased compared with prior to intubation and showed significant difference to the Fentanyl group statistically (p<0.001). Using Fentanyl as a premedication before laryngoscopy and endotracheal intubation is less effective than Clonidine to control of hemodynamic parameters in opium-dependent patients.

Diabetes mellitus is associated by increased blood glucose level resulting from lack of Insulin or Insulin resistance in peripheral tissues or both. The aim of this study was to investigate the effects of Nigella sativa L. seed hydroalcoholic extract on blood biochemical parameters in STZ-induced diabetic rats. This interventional study was done on 60 male Wistar rats. Animals were randomly divided into 6 groups (n=10) including control, diabetic (receiving saline), groups receiving 100, 200 and 400mg/kg doses of the extract and positive control (receiving 300mg/kg Metformin). Animals were treated for 6 weeks with gavage from start (zero), 24 and 45 days of the study. Glucose, cholesterol, triglycerides, HDL and LDL were measured after 12hours of fasting. Data were analyzed by SPSS 16 software and One-way ANOVA, Tukey and Paired-T tests. Blood sugar levels in diabetic rats receiving 200mg/kg dose of the extract was reduced more significantly than other treated groups (p<0.01). There was a significant difference in cholesterol and triglyceride at day 45 in all treated groups compared to diabetic group (p<0.001). No significant difference was observed in HDL in groups. A significant reduction in LDL was observed in diabetic group treated with Metformin and Nigella extract at day 45. Nigella sativa L. extract reduces glucose, cholesterol, triglyceride, and LDL levels in diabetic rats.

Today, obesity is one of the major health problems of human society. This study aimed to investigate the effect of 8 weeks Pilates on cortisol and lipid profile in obese women. This quasi-experimental study was done on 20 non-athletes 40±5year old obese women with BMI higher than 30kg in 2013 in Najaf Abad; Isfahan. Samples were divided into Pilates (n=10) and control group (n=10). Pilates Group were performed Pilates exercises 3 times per week for 8 weeks, each session 60 min, while control group just were followed. Lipids, including HDL, LDL, triglycerides before and 48h after 8 weeks were measured. Data were analyzed by SPSS 19 and independent and correlational-T test. 8 week Pilates significantly reduced weight (p=0.02), BMI (p=0.01), cholesterol (p=0.01), LDL (p=0.001) and a significant increase in cortisol in obese women in the exercise group compared with the control group. Pilates, decreases weight and body mass index, cholesterol and LDL and increases cortisol.

Emotions and how to deal with them are part of the human personality and affect her health. Ability to evaluate and express our emotions, emotion regulation of ourselves and the others and operation of emotion is called "emotional intelligence". This study aimed to determine the effect of emotional intelligence component training on self-efficacy enhancement and reduction of occupational stress. The semi-experimental research was done on Tehran municipality employees in 2010. Purposeful cluster sampling was done and 30 people who had a high score of occupational stress and low occupational stress were selected and randomly assigned to experimental and control groups. Data collected by the Self-Efficacy Beliefs Questionnaire developed by Scherer and colleagues and the Occupational Stress Inventory developed by Philip L. Rice. Data were analyzed by software SPSS 16 using descriptive statistics and independent T-test and Pearson's correlation coefficient. Self-efficacy mean score of experimental group was 64.9±6.2 in post-test which had a significant difference with pre-test score (51.9±8.5) of this group (t=5.1; p=0.05). The mean score of general symptoms of stress of experimental group was 25.7±6.8 in post-test which was significantly different from its pre-test score (32.1±5.6). A negative correlation was observed between self-efficacy increase and occupational stress symptoms reduction (r=-0.223; p=0.033). Teaching emotional intelligence components can increase the belief of self-efficacy and reduce the syndromes of occupational stress.

Wound healing is a complex physiological process involves a series of successive stages of hemostasis, inflammation, proliferation, and regeneration. This study aimed to investigate the effect of hydroalcoholic extract of Brassica oleracea L. (var. capitata) leaves in comparison with Phenytoin on epithelial layer healing and the holes in the skin of mice. This study was done on 40 male NIH Mice between 25-30gr. Animals were randomly divided into 4 groups (n=10). Negative control group received saline, positive control group administrated with 1% Phenytoin and treated groups received 10% and 20% hydroalcoholic extract twice a day until closing holes. Macroscopic and microscopic analysis was performed on days 1, 4, 7, 12 and 15. Statistical analysis was done by SPSS 16 software and Tukey test. A significant reduction was observed in average size of holes in 20% hydroalcoholic extract treated group compared to the negative control 10% extract at day 7 (p=0.001). There was a significant reduction in average size of holes in 20% extract group compared to 10% extract and negative control groups at day 12. (p=0.007). The skin holes in 20% extract group were closed earlier than the other groups. Epithelial thickness was increased in 20% extract group from 7th day the much faster than other groups. Brassica oleracea L. (var. capitata) has the same effect of phenytoin in healing of rapid closure of holes and proliferation of epithelial cells.